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Browsing by Author "McMahon, JB"

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  • Alexandre, Kabamba B; Gray, ES; Pantophlet, R; Moore, PL; McMahon, JB; Chakauya, E; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (American Society for Microbiology, 2011-09)
    The glycans on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study, the authors ...
  • Alexandre, Kabamba B; Gray, ES; Pantophlet, R; Moore, PL; McMahon, JB; Chakauya, E; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (American Society for Microbiology, 2011-09)
    The glycans on HIV-1 gp120 play an important role in shielding neutralization sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study we investigated ...
  • Alexandre, Kabamba B; Gray, ES; Mufhandu, Hazel T; McMahon, JB; Chakauya, E; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (Elsevier, 2012-02)
    It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and ...
  • Alexandre, Kabamba B; Moore, PL; Nonyane, M; Gray, ES; Ranchobe, N; Chakauya, E; McMahon, JB; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (Elsevier, 2013-11)
    We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 ...