ResearchSpace
→
Browsing by Author

Browsing by Author "Matshe, William MR"

Now showing items 1-7 of 7

Nanomedicines for malaria chemotherapy: Encapsulation vs. polymer therapeutics

Author: Mvango, Sindisiwe ; Matshe, William MR ; Balogun, AO ; Pilcher, LA ; Balogun, Mohammed O Date: Dec 2018 Malaria is one of the oldest infectious diseases that afflict humans and its history extends back for millennia. It was once prevalent throughout the globe but today it is mainly endemic to tropical regions like sub-Saharan Africa and South-east ... Read more
Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy

Author: Aderibigbe, BA ; Naki, T ; Steenkamp, V ; Nwamadi, M ; Ray, Suprakas S ; Balogun, Mohammed O ; Matshe, William MR Date: Sep 2019 Platinum-based drugs are potent anticancer drugs and are effective for the treatment of various cancers. However, they are limited pharmacologically due to toxic side effects, drug resistance and poor water solubility. In order to overcome ... Read more
Polyamidoamine drug conjugates containing metal-based anticancer compounds

Author: Aderibigbe, BA ; Mugogodi, A ; Nwamadi, M ; Ray, Suprakas S ; Steenkamp, V ; Balogun, Mohammed O ; Matshe, William MR Date: Sep 2019 Polyamidoamine drug conjugates containing ferrocene and platinum analogues were prepared in this study. Fourier transform infrared spectra confirmed the successful isolation of the conjugates with signals at 3300 cm-1 for amide N–H stretch ... Read more
Polymer-drug conjugates containing antimalarial drugs and antibiotics

Author: Alven, S ; Aderibigbe, BA ; Balogun, Mohammed O ; Matshe, William MR ; Ray, Suprakas S Date: Oct 2019 Most of the currently used antimalarial drugs suffer from drug resistance, poor bioavailability and biodegradability, drug toxicity and poor water solubility. To overcome some of the aforementioned limitations, combination therapy involving ... Read more
Synthesis of a novel amphiphilic nano-chitosan material

Author: Matshe, William MR ; Tshweu, Lesego L ; Balogun, Mohammed O Date: Oct 2018 Chitosan (CS) is a semi-synthetic polysaccharide derived from the most abundant naturally occurring polymer, chitin. It has found applications in fields as diverse as health, cosmetics, agriculture, environmental remediation etc. While ... Read more
Synthesis, characterization and in vitro analysis of polymer-based conjugaes containing dihydrofolate reductase inhibitors

Author: Aderibigbe, AB ; Mhlatika, Z ; Nwamadi, M ; Balogun, Mohammed O ; Matshe, William MR Date: Feb 2019 Malaria is an acute disease that is caused by the protozoanPlasmodiumparasites. Drug resistance is the majorproblem that is hindering the control of this disease. In order to overcome drug resistance to commonly usedantimalarials, nanocarriers ... Read more
Synthesis, characterization and in vitro analysis of polymer-based conjugates containing dihydrofolate reductase inhibitors

Author: Aderibigbe, BA ; Mhlwatika, Z ; Nwamadi, M ; Balogun, Mohammed O ; Matshe, William MR Date: Apr 2019 Malaria is an acute disease that is caused by the protozoan Plasmodium parasites. Drug resistance is the major problem that is hindering the control of this disease. In order to overcome drug resistance to commonly used antimalarials, ... Read more

Now showing items 1-7 of 7

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Tel: + 27 12 841 2911
Email: callcentre@csir.co.za

Physical Address
Meiring Naudé Road
Brummeria
Pretoria
South Africa

Postal Address
PO Box 395
Pretoria 0001
South Africa

Social Connect

Resources on this site are free to download and reuse according to associated licensing provision. Please read the terms and conditions of usage of each resource.

Browsing by Author "Matshe, William MR"

Browsing by Author "Matshe, William MR"

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Social Connect