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Browsing by Author "Malatji, Kanyane"

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Comparison of the antiviral activity of the microbicide candidate griffithsin and its tandemers derivatives against different modes of HIV-1 transmission

Author: Alexander, Kabamba ; Malatji, Kanyane ; Mulaudzi, Takalani Date: May 2020 Tandemers 2MG, 2MG3, 3MG and 4MG are derivatives of the potent anti-HIV-1 microbicide candidate griffithsin (GRFT). We compared these compounds anti-HIV-1 activity to GRFT using the viruses CAP206.08 and CAAN5342.A2 that have decreased ... Read more
Development of a multiplex HIV/TB diagnostic assay based on the microarray technology

Author: Malatji, Kanyane ; Singh, Advaita A ; Thobakgale, C ; Alexandre, Kabamba Date: Sep 2023 Currently there are diagnostic tests available for human immunodeficiency virus (HIV) and tuberculosis (TB); however, they are still diagnosed separately, which can delay treatment in cases of co-infection. Here we report on a multiplex ... Read more
In vitro study on efficacy of PHELA, an African traditional drug against SARS-CoV-2

Author: Matsabisa, MG ; Alexandre, Kabamba B ; Ibeji, CU ; Tripathy, S ; Erukainure, OL ; Malatji, Kanyane ; Chauke, Sipho H ; Okole, Blessed N ; Chabalal, HB Date: Jun 2022 In 2019, coronavirus has made the third apparition in the form of SARS-CoV-2, a novel strain of coronavirus that is extremely pathogenic and it uses the same receptor as SARS-CoV, the angiotensin converting enzyme 2 (ACE2). However, more than ... Read more
Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Author: Singh, Advaita A ; Pillay, Priyen ; Naicker, Previn ; Alexandre, Kabamba B ; Malatji, Kanyane ; Mach, L ; Steinkellner, H ; Vorster, J ; Chikwamba, Rachel K ; Tsekoa, Tsepo L Date: Aug 2022 The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases. This includes the induction of the expression of ... Read more

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Browsing by Author "Malatji, Kanyane"

Browsing by Author "Malatji, Kanyane"

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