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Browsing by Author "Malabi, Rudzani"

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Biocongugation of gold nanoparticles for surface plasmon resonance sensor

Author: Manoto, Sello L ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2019 Over the past few years gold nanoparticle (AuNPs) have become extremely interesting because they possess enhanced optical, electrical and chemical properties. AuNPs have the ability to form robust conjugates with biomolecules such as antibodies ... Read more
Design and FDTD simulation of photonic crystal based sensor for biosensing applications

Author: Manoto, Sello L ; Mabena, Chemist M ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2019 Photonic crystals (PhCs) is a unique and flexible class of optical devices that are able to manipulate the electromagnetic fields of light. PhCs is a subwavelength grating structure with a periodic arrangement of a high refractive index layer ... Read more
Detection of biological analytes using surface plasmon resonance as a biosensing technique for possible development of a point of care diagnostic tool

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, Malik ; Mthunzi-Kufa, Patience Date: Feb 2019 Surface Plasmon Resonance (SPR) is a very powerful optical sensing technique that detects bimolecular binding interactions and it has turned out to be a suitable platform for clinical analysis. In biological and chemical sensing applications, ... Read more
Development of collinear transmission plasmonic biosensor for detection of HIV-1

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Mthunzi-Kufa, Patience Date: Feb 2020 Surface Plasmon Resonance (SPR) which is widely used to study interactions between different types of biomolecules, has emerged as a technique of choice for rapid and quantitative analyses. However, there are still some challenges on the use ... Read more
Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles

Author: Oluwole, DA ; Manoto, Sello L ; Malabi, Rudzani ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience ; Nyokong, T Date: Mar 2018 We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical ... Read more
Exploring optical spectroscopic techniques and nanomaterials for virus detection

Author: Manoto, Sello L ; El-Hussein, A ; Malabi, Rudzani ; Thobakgale, Setumo L ; Ombinda-Lemboumba, Saturnin ; Attia, YA ; Kasem, MA ; Mthunzi-Kufa, Patience Date: Aug 2020 Viral infections pose significant health challenges globally by affecting millions of people worldwide and consequently resulting in a negative impact on both socioeconomic development and health. Corona virus disease 2019 (COVID-19) is a ... Read more
Growth and characterisation of gold thin film layer using an ebeam evaporation system for surface plasmon resonance applications

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Khanyile, S ; Khamlich, S ; Maaza, M ; Mthunzi-Kufa, Patience Date: Apr 2019 Gold thin metal layers have been seen to be the most important signal amplification components in electrochemical and optical sensor applications. In surface plasmon resonance (SPR) applications, gold thin metal film possess electron densities ... Read more
In-vitro photo-translocation of antiretroviral drug delivery into TZMbl cells

Author: Malabi, Rudzani ; Manoto, Sello L ; Maaza, M ; Mthunzi-Kufa, Patience ; Ombinda-Lemboumba, Saturnin Date: Jan 2017 The objectives of this study are to use femtosecond laser pulses in a photo-translocation system to deliver ARVs into HIV infected TZMbl cells, and to investigate the influence of ARVs and laser on cellular processes using different molecular ... Read more
In-vitro photo-translocation of antiretroviral drug delivery into TZMbl cells

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 The current human immunodeficiency virus (HIV) treatment regime possesses the ability to diminish the viral capacity to unnoticeable levels; however complete eradication of the virus cannot be achieved while latent HIV-1 reservoirs go ... Read more
Investigation of HIV-1 infected and uninfected cells using the optical trapping technique

Author: Ombinda-Lemboumba, Saturnin ; Malabi, Rudzani ; Lugongolo, Masixole Y ; Thobakgale, Setumo L ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2017 Optical trapping has emerged as an essential tool for manipulating single biological material and performing sophisticated spectroscopy analysis on individual cell. The optical trapping technique has been used to grab and immobilize cells ... Read more
Investigation of HIV-1 infected and uninfected cells using the optical trapping technique

Author: Ombinda-Lemboumba, Saturnin ; Malabi, Rudzani ; Lugongolo, Masixole Y ; Thobakgale, Setumo L ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2017 Optical trapping has emerged as an essential tool for manipulating single biological material and performing sophisticated spectroscopy analysis on individual cell. The optical trapping technique has been used to grab and immobilize cells ... Read more
Label-free differentiation of human immunodeficiency virus-1 infected from uninfected cells using transmission measurement

Author: Malabi, Rudzani ; Lugongolo, Masixole Y ; Thobakgale, Setumo L ; Manoto, Sello L ; Mthunzi-Kufa, Patience ; Ombinda-Lemboumba, Saturnin Date: Feb 2019 Transmission measurement has been perceived as a potential candidate for label-free investigation of biological material. It is a real-time, label-free and non-invasive optical detection technique that has found wide applications in pharmaceutical ... Read more
Laser-enhanced drug delivery of antiretroviral drugs into human immunodeficiency virus-1 infected TZMbl cells

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, Malik ; Mthunzi-Kufa, Patience Date: May 2019 The introduction of highly active antiretroviral therapy (HAART) has significantly increased life expectancy and improved management of the human immunodeficiency virus-1 (HIV-1) disease globally. This well-established treatment regime has ... Read more
Optimizing and characterizing a home-built Raman spectroscopy optical system using polystyrene microspheres

Author: Thobakgale, Setumo L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience ; Malabi, Rudzani Date: Feb 2019 In the recent decade, Raman spectroscopy has played a key role in photonics as a powerful method suited for detection, diagnosis and screening applications across various industrial fields. In this work, we propose a home built Raman Spectroscopy ... Read more
Phototodynamic activity of zinc monocarboxyphenoxy phthalocyane (ZnMCPPc) conjugated to gold silver (AuAg) nanoparticles in melanoma cancer cells

Author: Manoto, Sello L ; Oluwole, DO ; Malabi, Rudzani ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Nyokong, T ; Mthunzi-Kufa, Patience Date: Feb 2017 Photodynamic therapy (PDT) is a minimally invasive therapeutic modality for the treatment of neoplastic and non-neoplastic diseases. In PDT of cancer, irradiation with light of a specific wavelength leads to activation of a photosensitizer, ... Read more
Pros and cons of characterising an optical translocation setup

Author: Maphanga, Charles P ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Feb 2017 The delivery of genetic material and drugs into mammalian cells using femtosecond (fs) laser pulses is escalating rapidly. This novel light based technique achieved through a precise focusing of a laser beam on the plasma membrane is called ... Read more
Raman spectroscopy and gold thin film for biosensing and detection

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Thobakgale, Setumo L ; Lugongolo, Masixole Y ; Mthunzi-Kufa, Patience Date: Feb 2020 Raman spectroscopy is commonly used for sample characterization in biology because vibrational information is very specific to the chemical bonds in molecules. This makes it an attractive approach for identification of biological materials ... Read more
Surface Plasmon Resonance as a biosensing technique for possible development of a point of care diagnostic tool

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Sep 2018 Surface plasmon resonance is an optical sensing technique with the ability to monitor molecular binding in real time for biological and chemical sensing applications. This study characterised, optimised and detected biological analytes using ... Read more

Now showing items 1-18 of 18

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