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Browsing by Author "Makola, MM"

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Effect of geometrical isomerism of 3,5-dicaffeoylquinic acid on its binding affinity to HIV-integrase enzyme: a molecular docking study

Author: Makola, MM ; Dubery, IA ; Koorsen, G ; Steenkamp, Paul A ; Kabanda, MM ; Du Preez, LL ; Madala, NE Date: 2016 A potent plant-derived HIV-1 inhibitor, 3,5-dicaffeoylquinic acid (diCQA), has been shown to undergo isomerisation upon UV exposure where the naturally occurring, 3(suptrans), 5(suptrans)-diCQA isomer gives rise to the 3(supcis), 5(suptrans)-diCQA, ... Read more c b
Influence of the geometric isomers on the radical scavenging properties of 3,5-dica®eoylquinic acid: A DFT study in vacuo and in solution

Author: Makola, MM ; Madala, NE ; Dubery, IA ; Steenkamp, Paul A ; Kabanda, MM Date: Sep 2016 3,5-Dica®eoylquinic acid (diCQA) is a part of the chlorogenic acid group of compounds, largely isolated from food sources and possessing potent antioxidant activity. Only the trans–trans isomer exists in nature, however, abiotic stresses, ... Read more
Preferential alkali metal adduct formation by cis geometrical isomers of dicaffeoylquinic acids allows for efficient discrimination from their trans isomers during ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Author: Makola, MM ; Steenkamp, Paul A ; Dubery, IA ; Kabanda, MM ; Madala, NE Date: Mar 2016 Caffeoylquinic acid (CQA) derivatives are a group of structurally diverse phytochemicals that have attracted attention due to their many health benefits. The structural diversity of these molecules is due in part to the presence of regio- and ... Read more

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Browsing by Author "Makola, MM"

Browsing by Author "Makola, MM"

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