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Browsing by Author "Lugongolo, Masixole Y"

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Characterisation of a Bessel beam optical cell sorting system using microspheres

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2020 Accurate sorting of specific particles in a mixed population is a desirable capability in the field of biomedical sciences. This enables researchers to purify samples by selecting only the particles of interest. Optical sorting is achieved ... Read more
The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jun 2020 Human immunodeficiency virus (HIV) infection remains a global health challenge despite the use of antiretroviral therapy, which has led to a significant decline in the mortality rates. Owing to the unavailability of an effective treatment to ... Read more
Could low level laser therapy and highly active antiretroviral therapy lead to complete eradication of HIV-1 in vitro?

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine or a ... Read more
The effects of low level laser therapy on both HIV-1 infected and uninfected TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and ... Read more
Examining HIV infected cells using optical trapping and Raman spectroscopy

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Sep 2021 Manipulation of biological cells using optical trapping is a non-invasive approach in which individual living cells are examined without causing any damage because there is no direct mechanical contact with cells. Optical trapping uses a ... Read more
Examining HIV infected cells using optical trapping and Raman spectroscopy

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Sep 2021 Manipulation of biological cells using optical trapping is a non-invasive approach in which individual living cells are examined without causing any damage because there is no direct mechanical contact with cells. Optical trapping uses a ... Read more
Investigation of HIV-1 infected and uninfected cells using the optical trapping technique

Author: Ombinda-Lemboumba, Saturnin ; Malabi, Rudzani ; Lugongolo, Masixole Y ; Thobakgale, Setumo L ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2017 Optical trapping has emerged as an essential tool for manipulating single biological material and performing sophisticated spectroscopy analysis on individual cell. The optical trapping technique has been used to grab and immobilize cells ... Read more
Investigation of HIV-1 infected and uninfected cells using the optical trapping technique

Author: Ombinda-Lemboumba, Saturnin ; Malabi, Rudzani ; Lugongolo, Masixole Y ; Thobakgale, Setumo L ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2017 Optical trapping has emerged as an essential tool for manipulating single biological material and performing sophisticated spectroscopy analysis on individual cell. The optical trapping technique has been used to grab and immobilize cells ... Read more
Label-free detection of HIV-1 infected cells via integration of optical tweezers and photoluminescence spectroscopy

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Noto, LN ; Maaza, M ; Mthunzi-Kufa, Patience Date: Feb 2018 The human immunodeficiency virus-1 (HIV-1) is currently detected using conventional qualitative and quantitative tests to determine the presence or absence of HIV in blood samples. However, the approach of these tests detects the presence of ... Read more
Label-free detection of mutations in the HIV genome using a surface plasmon resonance biosensor

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Thobakgale, Setumo L ; Mthunzi-Kufa, Patience Date: Mar 2021 Surface plasmon resonance (SPR) biosensors are optical materials that measure changes in the refractive index as they monitor non-covalent molecular interactions in real time. These utilise a label free analytical approach, which does not ... Read more
Label-free differentiation of human immunodeficiency virus-1 infected from uninfected cells using transmission measurement

Author: Malabi, Rudzani ; Lugongolo, Masixole Y ; Thobakgale, Setumo L ; Manoto, Sello L ; Mthunzi-Kufa, Patience ; Ombinda-Lemboumba, Saturnin Date: Feb 2019 Transmission measurement has been perceived as a potential candidate for label-free investigation of biological material. It is a real-time, label-free and non-invasive optical detection technique that has found wide applications in pharmaceutical ... Read more
Laser irradiation reduces HIV-1 infection in TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Oct 2016 HIV-1 epidemic remains a major health challenge. This study explores the effects of low level laser therapy on HIV-1 infected cells. Infection is reduced by irradiation and the mechanism needs to be investigated further. Read more
Point of care diagnostics for HIV in resource limited settings: an overview

Author: Manoto, Sello L ; Lugongolo, Masixole Y ; Govender, Ureshnie ; Mthunzi-Kufa, Patience Date: Mar 2018 Human immunodeficiency virus (HIV) is a global health problem. Early diagnosis, rapid antiretroviral therapy (ART) initiation and monitoring of viral load are the key strategies for effective HIV management. Many people in resource limited ... Read more
Raman spectroscopy and gold thin film for biosensing and detection

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Thobakgale, Setumo L ; Lugongolo, Masixole Y ; Mthunzi-Kufa, Patience Date: Feb 2020 Raman spectroscopy is commonly used for sample characterization in biology because vibrational information is very specific to the chemical bonds in molecules. This makes it an attractive approach for identification of biological materials ... Read more
Smartphone biosensing for point of care diagnostics

Author: Manoto, Sello L ; Mabena, Chemist M ; Malabi, Khorommbi P ; Ombinda-Lemboumba, Saturnin ; El-Hussein, A ; Kasem, M ; Lugongolo, Masixole Y ; Mthunzi-Kufa, Patience Date: Feb 2020 A lot of individuals residing in resource limited settings where timely access to medical care is a challenge and healthcare infrastructure is usually poor have no access to laboratory facilities. Disease diagnosis in such sites is dependent ... Read more

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