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Browsing by Author "Lemmer, Y"

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  • Lemmer, Yolandy; Thanyani, ST; Vrey, PJ; Driver, CHS; Venter, L; Van Wyngaardt, S; Ten Bokum, AMC; Ozoemena, KI; Pilcher, LA; Fernig, DG; Stoltz, AC; Swai, HS; Verschoor, JA (Elsevier, 2009)
    Antibodies to mycolic acid (MA) antigens can be detected as surrogate markers of active tuberculosis (TB) with evanescent field biosensors where the lipid antigens are encapsulated in liposomes. Standard immunoassay such ...
  • Semete, B; Booysen, L; Lemmer, Yolandy; Kalombo, Lonji; Katata, L; Verschoor, J; Swai, HS (Elsevier, 2010-10)
    The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some ...
  • Lemmer, Yolandy; Semete, B; Kalombo, Lonji; Ramalapa, B; Jones, AT; Swai, HS; Verschoor, JA (CSIR, 2010-09-01)
    Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. ...
  • Lemmer, Yolandy; Kalombo, Lonji; Pietersen, R-D; Jones, AT; Semete-Makokotlela, Boitumelo; Van Wyngaardt, S; Ramalapa, BE; Stoltz, A; Baker, B; Verschoor, JA; Swai, HS; De Chastellier, C (Elsevier, 2015-06)
    The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate ...
  • Hayeshi, R; Semete, B; Kalombo, Lonji; Katata, L; Lemmer, Yolandy; Melariri, P; Nyamboli, B; Swai, H (Springer-Verlag, 2012)
    Nanotechnology is a multidisciplinary field covering the design, manipulation, characterisation, production and application of structures, devices and systems at nanometer scale (1–500-nm-size range) which, at this size ...
  • Mhlanga, N; Sinha Ray, S; Lemmer, Yolandy; Wesley-Smith, J (ACS Publications, 2015-09)
    To improve traditional cancer therapies, we synthesized polylactide (PLA) spheres coencapsulating magnetic nanoparticles (MNPs, Fe(sub3)O(sub4)) and an anticancer drug (doxorubicin, DOX). The synthesis process involves the ...
  • Semete, B; Kalombo, Lonji; Katata, L; Chelule, P; Booysen, L; Lemmer, Yolandy; Naidoo, S; Ramalapa, B; Hayeshi, R; Swai, HS (Taylor & Francis, 2012-03)
    Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single ...
  • Hayeshi, R; Semete, B; Kalombo, Lonji; Lemmer, Yolandy; Katata, L; Swai, H (CRC Netbase, 2013-11)
    Nanotechnology is a multidisciplinary field that encompasses the design, manipulation, characterization, production, and application of structures, devices, and systems at the nanometer scale range (~1–500 nm), which present ...
  • Lemmer, Yolandy (2010-06)
    South Africa currently has the highest incidence of TB per 100 000 people in the world. In 2007 alone 112 000 people died of TB in South Africa, of which 94 000 were co-infected with HIV (1). Although TB treatments exist, ...
  • Lemmer, Yolandy; Semete, B; Booysen, L; Kalombo, Lonji; Katata, L; Jones, AT; Alexander, C; Khati, M; Swai, HS; Verschoor, JA (2010-06)
    South Africa currently has the highest incidence of TB per 100000 (358 per 100000) people in the world. In 2007 alone 112000 people died of TB in South Africa, of which 94 000 (72%) were co-infected with HIV. Although TB ...
  • Lemmer, Yolandy; Siko, G; Swai, H; Verschoor, J (2009-08)
    This poster is the first demonstration of the use of the evanescent field biosensor to show the interaction between low molecular weight ligate/ligand pairs. The authors demonstrated the interaction of Amphotericin B to ...