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Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control

Author: Owen, GR ; Le, D ; Stoychev, Stoyan H ; Cerutti, NM ; Papathanasopoulos, M Date: Mar 2018 CD4, a membrane glycoprotein expressed by specific leukocytes, plays a vital role in the human immune response and acts as a primary receptor for HIV entry. Of its four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide ... Read more

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Browsing by Author "Le, D"

Browsing by Author "Le, D"

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