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Browsing by Author "Khan, T"

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  • Bode, M; Gledhill, Irvy MA; Gravestock, D; Hoppe, H; Khan, T; Moleele, S; Nkabinde, L; Pelly, S; van der Westhuyzen, C (CSIR, 2010-09)
    A compound possessing anti-HIV activity similar to that of FDA-approved nevirapine was developed. It acts as a non-nucleoside reverse transcriptase inhibitor, the compound shows good cell permeability, and a quantitative ...
  • Bode, ML; Gravestock, D; Moleele, SS; Van der Westhuyzen, CW; Pelly, SC; Steenkamp, PA; Hoppe, HC; Khan, T; Nkabinde, LA (Elsevier, 2011-06)
    During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds ...
  • Bode, ML; Gravestock, D; Moleele, S; Van Der Westhuyzen, CW; Hoppe, H; Khan, T; Pelly, SC (2010-01)
    The enzyme reverse transcriptase (RT) is a validated target for the development of anti-HIV drugs. Drugs acting against RT may act at either the catalytic site (NRTIs) or the allosteric site (NNRTIs). During random screening ...