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Browsing by Author "Kalombo, Lonji"

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99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles

Author: Mandiwana, Vusani ; Kalombo, Lonji ; Grobler, A ; Zeevaart, JR Date: Nov 2018 The aim of this study was to establish the in vivo uptake and tissue distribution of (sup)99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive (sup)99mTc-MDP encapsulated into SLNs was administered to rats ... Read more
Design and formulation of nano-sized spray dried Efavirenz-Part 1: Influence of formulation parameters

Author: Tshweu, L ; Katata, L ; Naidoo, Saloshnee ; Kalombo, Lonji ; Swai, H Date: Oct 2012 AIDS kills over 1.5 million people a year globally. Current HIV drugs pose many challenges. This presentation shows that nano-encapsulation of HIV drugs achieves controlled and steady drug release, and reduced dosing frequency. Read more
Design and formulation of nano-sized spray dried efavirenz. Part I: Influence of formulation parameters

Author: Katata, L ; Tshweu, L ; Naidoo, Saloshnee ; Kalombo, Lonji ; Swai, H Date: Oct 2012 Efavirenz (EFV) is one of the first-line antiretroviral drugs recommended by the World Health Organisation for treating HIV. It is a hydrophobic drug that suffers from low aqueous solubility (4 lg/mL), which leads to a limited oral absorption ... Read more
Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration

Author: Semete, B ; Booysen, L ; Kalombo, Lonji ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study aims to elucidate the ... Read more
Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix

Author: Mlalila, N ; Swai, H ; Kalombo, Lonji ; Hilonga, A Date: Dec 2014 The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using ... Read more
Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD)

Author: Swai, H ; Hillie, KT ; Cingo, N ; Kalombo, Lonji ; Legodi, M ; Semete, B Date: Feb 2006 In this study, isoniazid, one of the most potent anti-TB drugs, was successfully encapsulated in poly (D, L- lactide-co-glycolide) (PLG) and in alginate-chitosan polymeric systems using a double-emulsion method and a cation-induced gelation ... Read more
The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system combined drug delivery system

Author: Chelopo, MP ; Kalombo, Lonji ; Wesley-Smith, J ; Grobler, A ; Hayeshi, R Date: Mar 2017 The combination of polymeric nanoparticles (NPs) as a core and lipid vesicles as a shell has emerged to be a robust and promising drug delivery strategy. This study explores the development of a novel combined delivery system where poly d,l, ... Read more
In vitro characterisation of PLGA nanoparticles encapsulating rifampicin and isoniazid - Towards IVIVC

Author: Booysen, L ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, H ; Kotzé, AF Date: 01 Sep 2010 It has been postulated that antituberculosis drugs encapsulated in polymeric nanoparticles are able to control the release of these drugs in vivo. These biodegradable polymers facilitate sustained/controlled release by means of degradation ... Read more
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems

Author: Semete, B ; Booysen, L ; Lemmer, Yolandy ; Kalombo, Lonji ; Katata, L ; Verschoor, J ; Swai, HS Date: Oct 2010 The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some concerns. The aim of ... Read more
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Author: Booysen, LLIJ ; Kalombo, Lonji ; Brooks, E ; Hansen, R ; Gilliland, J ; Gruppo, V ; Lungenhofer, P ; Semete-Makokotlela, Boitumelo ; Swai, HS ; Kotze, AF ; Lenaerts, A ; du Plessis, LH Date: Feb 2013 Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to ... Read more
Lipid containing nanodrug delivery system for the treatment of Tuberculosis

Author: Lemmer, Yolandy ; Semete, B ; Kalombo, Lonji ; Ramalapa, B ; Jones, AT ; Swai, HS ; Verschoor, JA Date: 01 Sep 2010 Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. To improve the ... Read more
Micronization, characterization and in-vitro dissolution of shellac from PGSS supercritical CO2 technique

Author: Labuschagne, Philip W ; Naicker, B ; Kalombo, Lonji Date: Feb 2016 The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the particles from gas saturated solution (PGSS) process and ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanoencapsulation of Mycolic acids as a deliverable to macrophages

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Jun 2008 The cell wall envelope of Mycobacterium tuberculosis contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids, an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 carbon atoms in length, ... Read more
Nanoencapsulation of mycolic acids as a deliverable to macrophages - 2nd CSIR Biennial Conference

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Nov 2008 The objective of this project was to explore the encapsulation of mycolic acids into vehicles other than liposomes for delivery into macrophages and addressing the challenges of low solubility. As vehicles nanoparticles (NP) have the advantage ... Read more
Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment

Author: Tshweu, L ; Katata, L ; Kalombo, Lonji ; Swai, H Date: Oct 2013 Current treatments available for human immunodeficiency virus, namely antiretrovirals, do not completely eradicate the virus from the body, leading to life-time commitment. Many antiretrovirals suffer drawbacks from toxicity and unpleasant ... Read more
Nanomedicine in the development of drugs for poverty-related diseases

Author: Hayeshi, R ; Semete, B ; Kalombo, Lonji ; Katata, L ; Lemmer, Yolandy ; Melariri, P ; Nyamboli, B ; Swai, H Date: 2012 Nanotechnology is a multidisciplinary field covering the design, manipulation, characterisation, production and application of structures, devices and systems at nanometer scale (1–500-nm-size range) which, at this size range, presents with ... Read more
Novel nanoparticles for Tuberculosis chemotherapy

Author: Semete, B ; Kalombo, Lonji ; Chelule, P ; Benadie, Y ; Booysen, L ; Katata, L ; Naidoo, Saloshnee ; Swai, H Date: Nov 2008 Current therapeutic management of tuberculosis is inadequate due to non-compliance, lengthy course of treatment and drug- related side effects. In order to address these setbacks, the authors are developing a nanotechnology drug delivery ... Read more
Permeation of PLGA nanoparticles across different in vitro models

Author: Nkabinde, LA ; Shoba-Zikhali, LN ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, HS ; Hayeshi, R ; Naicker, B ; Hillie, TK ; Hamman, JH Date: Jul 2012 Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake ... Read more
Potential of improving the treatment of tuberculosis through nanomedicine

Author: Semete, B ; Kalombo, Lonji ; Katata, L ; Chelule, P ; Booysen, L ; Lemmer, Yolandy ; Naidoo, Saloshnee ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains ... Read more

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