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Browsing by Author "Chhiba, V"

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  • Brady, D; Molefe, M; Steenkamp, Lucia H; Parkinson, C; Jordaan, J; Visser, Daniel F; Simpson, C; Chhiba, V; Mathiba, K (2006-11)
    It was found that the nitrile hydratases in microorganisms isolated from around the world had infra-species amino acid sequence differences, and this provided an explanation for the variability of nitrile substrate usage ...
  • Chhiba, V; Bode, M; Mathiba, K; Kwezi, Lusisizwe; Brady, D (Elsevier, 2012-04)
    A range of ß-aminonitriles (3-amino-3-phenylpropanenitrile and derivatives) were synthesised by reaction of various benzonitriles with acetonitrile and subsequent reduction of the resulting acrylonitrile products. These ...
  • Chhiba, V; Bode, M; Mathiba, K; Brady, D (Wiley, 2014-06)
    The use of enzymes for the enantioselective synthesis of single enantiomer ß-subsituted compounds is of interest, as this structural motif occurs commonly in compounds of pharmaceutical importance, such as adrenergic agents, ...