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Browsing by Author "Benadie, Y"

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  • Benadie, Y; Deysel, M; Siko, DGR; Roberts, VV; Van Wyngaardt, S; Thanyani, ST; Sekanka, G; Ten Bokum, AMC; Collett, LA; Grooten, J; Baird, MS; Verschoor, JA (Elsevier, 2008)
    Mycolic acids (MAs) are a major component of the cell walls of Mycobacterium tuberculosis and related organisms. These alpha-alkyl beta-hydroxy long fatty acids have been the subject of numerous studies for their immunological ...
  • Benadie, Y; Semete, B; Venter, L; Kalombo, Lonji; Driver, C; Jones, AT; Swai, H; Verschoor, JA (2008-06)
    The cell wall envelope of Mycobacterium tuberculosis contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids, an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 ...
  • Benadie, Y; Semete, B; Venter, L; Kalombo, Lonji; Driver, C; Jones, AT; Swai, H; Verschoor, JA (CSIR, 2008-11)
    The objective of this project was to explore the encapsulation of mycolic acids into vehicles other than liposomes for delivery into macrophages and addressing the challenges of low solubility. As vehicles nanoparticles ...
  • Semete, B; Kalombo, Lonji; Chelule, P; Benadie, Y; Booysen, L; Katata, L; Naidoo, S; Swai, H (CSIR, 2008-11)
    Current therapeutic management of tuberculosis is inadequate due to non-compliance, lengthy course of treatment and drug- related side effects. In order to address these setbacks, the authors are developing a nanotechnology ...