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Browsing by Author "Van Otterlo, WAL"

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Metathesis reactions for the synthesis of ring-fused carbazoles

Author: Pelly, SC ; Parkinson, CJ ; Van Otterlo, WAL ; De Koning, CB Date: 09 Dec 2005 The metathesis reaction is used as a key step for the synthesis of the indolo [2,3-a] carbazole core of rebeccamycin 13 and the sulfur analog of furostifoline 21. Using the same methodology for the attempted synthesis of furostifoline, the ... Read more
Modern methods for the sythesis of substituted naphthalenes

Author: De Koning, CB ; Rousseau, AL ; Van Otterlo, WAL Date: 01 Jan 2003 The importance of naphthalenes and naphthoquinones as bioactive agents and in structural and synthetic chemistry is discussed. How the synthetic chemist gains access to such compounds forms the subject of this review. The synthesis of ... Read more
Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Author: Panayides, Jenny-Lee ; Mathieu, V ; Banuls, LMY ; Apostolellis, H ; Dahan-Farkas, N ; Davids, H ; Harmse, L ; Rey, MEC ; Green, IR ; Pelly, SC ; Kiss, R ; Kornienko, A ; Van Otterlo, WAL Date: Jun 2016 Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a ... Read more
Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

Author: Mabank, T ; Alexandre, Kabamba B ; Pelly, SC ; Green, IR ; Van Otterlo, WAL Date: Jul 2019 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds ... Read more

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Browsing by Author "Van Otterlo, WAL"

Browsing by Author "Van Otterlo, WAL"

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