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Browsing by Author "Pilcher, LA"

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Physico-chemical characterization of polyethylene glycol-conjugated betulinic acid

Author: Mvango, Sindisiwe ; Mthimkhulu, N ; Fru, PA ; Pilcher, LA ; Balogun, Mohammed O Date: Nov 2020 Betulinic acid (BA) is a naturally occurring plant pentacyclic triterpenoid with activity against cancer and infectious diseases like malaria and AIDS. Its pharmacological activity is limited by low aqueous solubility and bioavailability. ... Read more
Synthesis and characterisation of quantum dots coupled to mycolic acids as a water-soluble fluorescent probe for potential lateral flow detection of antibodies and diagnosis of tuberculosis

Author: Kabwe, KP ; Nsibande, SA ; Lemmer, Yolandy ; Pilcher, LA ; Forbes, PBC Date: Nov 2021 This work explores the potential use of cadmium-based quantum dots (QDs) coupled to mycolic acids (MAs) as a fluorescent probe to detect anti-MA antibodies which are biomarkers for tuberculosis (TB). The use of free MAs as antigens for the ... Read more
Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin

Author: Tshweu, Lesego L ; Shemis, MA ; Abdelghany, C ; Gouda, A ; Pilcher, LA ; Sibuyi, NRS ; Meyer, M ; Dube, A ; Balogun, Mohammed O Date: May 2020 Antibiotic resistance is increasing at such an alarming rate that it is now one of the greatest global health challenges. Undesirable toxic side-effects of the drugs lead to high rates of non-completion of treatment regimens which in turn ... Read more

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Browsing by Author "Pilcher, LA"

Browsing by Author "Pilcher, LA"

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