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Browsing by Author "Pelly, SC"

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  • Bode, ML; Gravestock, D; Moleele, SS; Van der Westhuyzen, CW; Pelly, SC; Steenkamp, PA; Hoppe, HC; Khan, T; Nkabinde, LA (Elsevier, 2011-06)
    During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds ...
  • Bode, ML; Gravestock, D; Moleele, S; Van Der Westhuyzen, CW; Hoppe, H; Khan, T; Pelly, SC (2010-01)
    The enzyme reverse transcriptase (RT) is a validated target for the development of anti-HIV drugs. Drugs acting against RT may act at either the catalytic site (NRTIs) or the allosteric site (NNRTIs). During random screening ...
  • Pelly, SC; Parkinson, CJ; Van Otterlo, WAL; De Koning, CB (American Chemical Society, 2005-12-09)
    The metathesis reaction is used as a key step for the synthesis of the indolo [2,3-a] carbazole core of rebeccamycin 13 and the sulfur analog of furostifoline 21. Using the same methodology for the attempted synthesis of ...
  • Panayides, Jenny-Lee; Mathieu, V; Banuls, LMY; Apostolellis, H; Dahan-Farkas, N; Davids, H; Harmse, L; Rey, MEC; Green, IR; Pelly, SC; Kiss, R; Kornienko, A; Van Otterlo, WAL (Elsevier, 2016-06)
    Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds ...