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Browsing by Author "Kalombo, L"

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  • Lemmer, Yolandy; Semete, B; Kalombo, Lonji; Ramalapa, B; Jones, AT; Swai, HS; Verschoor, JA (CSIR, 2010-09-01)
    Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. ...
  • Labuschagne, Philip W; Naicker, B; Kalombo, Lonji (Elsevier, 2016-02)
    The purpose of this investigation was to determine whether shellac, a naturally occurring material with enteric properties, could be processed in supercritical CO2 (sc-CO2) using the particles from gas saturated solution ...
  • Lemmer, Yolandy; Kalombo, Lonji; Pietersen, R-D; Jones, AT; Semete-Makokotlela, Boitumelo; Van Wyngaardt, S; Ramalapa, BE; Stoltz, A; Baker, B; Verschoor, JA; Swai, HS; De Chastellier, C (Elsevier, 2015-06)
    The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate ...
  • Benadie, Y; Semete, B; Venter, L; Kalombo, Lonji; Driver, C; Jones, AT; Swai, H; Verschoor, JA (2008-06)
    The cell wall envelope of Mycobacterium tuberculosis contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids, an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 ...
  • Benadie, Y; Semete, B; Venter, L; Kalombo, Lonji; Driver, C; Jones, AT; Swai, H; Verschoor, JA (CSIR, 2008-11)
    The objective of this project was to explore the encapsulation of mycolic acids into vehicles other than liposomes for delivery into macrophages and addressing the challenges of low solubility. As vehicles nanoparticles ...
  • Tshweu, L; Katata, L; Kalombo, Lonji; Swai, H (Springer Verlag, 2013-10)
    Current treatments available for human immunodeficiency virus, namely antiretrovirals, do not completely eradicate the virus from the body, leading to life-time commitment. Many antiretrovirals suffer drawbacks from toxicity ...
  • Hayeshi, R; Semete, B; Kalombo, Lonji; Katata, L; Lemmer, Yolandy; Melariri, P; Nyamboli, B; Swai, H (Springer-Verlag, 2012)
    Nanotechnology is a multidisciplinary field covering the design, manipulation, characterisation, production and application of structures, devices and systems at nanometer scale (1–500-nm-size range) which, at this size ...
  • Semete, B; Kalombo, Lonji; Chelule, P; Benadie, Y; Booysen, L; Katata, L; Naidoo, S; Swai, H (CSIR, 2008-11)
    Current therapeutic management of tuberculosis is inadequate due to non-compliance, lengthy course of treatment and drug- related side effects. In order to address these setbacks, the authors are developing a nanotechnology ...
  • Nkabinde, LA; Shoba-Zikhali, LN; Semete-Makokotlela, Boitumelo; Kalombo, Lonji; Swai, HS; Hayeshi, R; Naicker, B; Hillie, TK; Hamman, JH (Bentham Science Publishers, 2012-07)
    Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance ...
  • Semete, B; Kalombo, Lonji; Katata, L; Chelule, P; Booysen, L; Lemmer, Yolandy; Naidoo, S; Ramalapa, B; Hayeshi, R; Swai, HS (Taylor & Francis, 2012-03)
    Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single ...
  • Omwoyo, WN; Ogutu, B; Oloo, F; Swai, H; Kalombo, Lonji; Melariri, P; Mahanga, GM; Waweru Gathirwa, JW (Dove Medical Press Limited, 2014-08)
    Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- ...
  • Hayeshi, R; Semete, B; Kalombo, Lonji; Lemmer, Yolandy; Katata, L; Swai, H (CRC Netbase, 2013-11)
    Nanotechnology is a multidisciplinary field that encompasses the design, manipulation, characterization, production, and application of structures, devices, and systems at the nanometer scale range (~1–500 nm), which present ...
  • Mandiwana, V; Kalombo, Lonji; Venter, Karien; Sathekge, M; Grobler, A; Zeevaart, JR (Springer, 2015-09)
    Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of ...
  • Lemmer, Yolandy; Semete, B; Booysen, L; Kalombo, Lonji; Katata, L; Jones, AT; Alexander, C; Khati, M; Swai, HS; Verschoor, JA (2010-06)
    South Africa currently has the highest incidence of TB per 100000 (358 per 100000) people in the world. In 2007 alone 112000 people died of TB in South Africa, of which 94 000 (72%) were co-infected with HIV. Although TB ...