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Browsing by Author "Chakauya, E"

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GMOs in Africa: opportunities and challenges in South Africa

Author: Bothma, G ; Mashaba, C ; Mkonza, N ; Chakauya, E ; Chikwamba, Rachel K Date: Aug 2010 Genetically modified organisms are expected to have a large impact on the ability of humanity to feed, fuel and heal itself in light of the growing global change, and adverse geo-climatic conditions anticipated as a result of climate change. ... Read more
The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

Author: Alexandre, Kabamba B ; Gray, ES ; Mufhandu, Hazel T ; McMahon, JB ; Chakauya, E ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Feb 2012 It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) ... Read more
Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

Author: Alexandre, Kabamba B ; Moore, PL ; Nonyane, M ; Gray, ES ; Ranchobe, N ; Chakauya, E ; McMahon, JB ; O'Keefe, BR ; Chikwamba, Rachel K ; Morris, L Date: Nov 2013 We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 strains cultured ... Read more
Morphological variation of sorghum landraces from semi-arid areas of Zimbabwe

Author: Mujaju, C ; Chakauya, E Date: 2008 Sorghum (Sorghum bicolor) is one of the most important cereal crops cultivated in, the semi-arid areas of Zimbabwe where persistent drought, high temperatures and poor edaphic conditions are endemic. Because of their adaptation, landraces are ... Read more
Progress and perspectives on HIV-1 microbicide development

Author: Alexandre, Kabamba B ; Mufhandu, Hazel T ; London, GM ; Chakauya, E ; Khati, M Date: Oct 2016 The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender ... Read more
Riding the tide of biopharming in Africa: considerations for risk assessment

Author: Chakauya, E ; Chikwamba, Rachel K ; Rybick, EP Date: Aug 2006 This article provides a background to biopharming, highlighting basic considerations for risk assessment and regulation in developing countries, with an emphasis on plant-based vaccines production in South Africa. Read more
Towards engineering increased pantothenate (Vitamin B5) levels in plants

Author: Chakauya, E ; Coxon, KM ; Wei, M ; MacDonald, MV ; Barsby, T ; Abell, C ; Smith, AG Date: Nov 2008 Pantothenate (vitamin B5) is the precursor of the 4'-phosphopantetheine moiety of coenzyme A and acyl-carrier protein. It is made by plants and microorganisms de novo, but is a dietary requirement for animals. The pantothenate biosynthetic ... Read more

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Browsing by Author "Chakauya, E"

Browsing by Author "Chakauya, E"

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