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Browsing by Author "Chakauya, E"

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  • Alexandre, Kabamba B; Gray, ES; Pantophlet, R; Moore, PL; McMahon, JB; Chakauya, E; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (American Society for Microbiology, 2011-09)
    The glycans on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study, the authors ...
  • Alexandre, Kabamba B; Gray, ES; Pantophlet, R; Moore, PL; McMahon, JB; Chakauya, E; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (American Society for Microbiology, 2011-09)
    The glycans on HIV-1 gp120 play an important role in shielding neutralization sensitive epitopes from antibody recognition. They also serve as targets for lectins that bind mannose-rich glycans. In this study we investigated ...
  • Grootboom, AW; Mkhonza, NL; O'Kennedy, MO; Chakauya, E; Kunert, K; Chikwamba, Rachel K (Asian Network for Scientific Information, 2010)
    Sorghum (Sorghum bicolor (L.) Moench) is recalcitrant to transformation and besides several reported cases of success, transformation is far from routine. The choice of the selectable markers is key factor influencing ...
  • Stark, T; Chakauya, E; Kabamba, A; Morris, L; Rybicki, E; Chikwamba, Rachel K (2010-08)
    Sub-Saharan Africa remains the region most heavily affected by HIV, and the majority of new infections from heterosexual contact are in women. Griffithsin (GRFT), a lectin isolated from the red algae Griffithsia, has shown ...
  • Stark, T; Chakauya, E; Kabamba, A; Morris, L; Rybicki, E; Chikwamba, Rachel K (CSIR, 2010-09-01)
    Due to the increasing demand for pharmaceuticals and the high cost of production in traditional fermentor systems, plants are being considered as alternative production platforms for therapeutic molecules. One of the ...
  • O'Kennedy, MM; Crampton, BG; Lorito, M; Chakauya, E; Breese, WA; Burger, JT; Botha, FC (Elsevier Publishers, 2011-05)
    Sclerospora graminicola is an Oomycete (heterotrophic Stramenopiles), fungal-like obligate phytopathogen, the causal agent of downy mildew in pearl millet (Pennisetum glaucum [L.] R. Br.), and a major constraint in the ...
  • Mawela, K; Lezar, S; Chakauya, E; Eloff, JN; Chikwamba, Rachel K (CSIR, 2010-09-01)
    HIV prevalence is over 33 million worldwide with 68% of AIDS sufferers residing in sub-Saharan Africa (1). Currently the available HIV prevention tools are feasible but women cannot insist on these preventive measures due ...
  • Meyers, A; Chakauya, E; Shepard, E; Tanzer, FL; Lynch, A; Williamson, A; Rybicki, EP (BioMed Central, 2008-06-23)
    Human immunodeficiency virus type 1 (HIV-1) has infected more than 40 million people worldwide, mainly in sub-Saharan Africa. The high prevalence of HIV-1 subtype C in southern Africa necessitates the development of cheap, ...
  • Zungu, N; Lotter, T; Dube, N; Chakauya, E; Lezar, S; Chikwamba, Rachel K (2008-01)
    Rabies, an important disease in Asia and Africa, is an acute viral disease of the central nervous system that affects humans and other mammals. Upon bites or contact with rabid animals patients are immediately immunized ...
  • Bothma, G; Mashaba, C; Mkonza, N; Chakauya, E; Chikwamba, Rachel K (Landes Bioscience, 2010-08)
    Genetically modified organisms are expected to have a large impact on the ability of humanity to feed, fuel and heal itself in light of the growing global change, and adverse geo-climatic conditions anticipated as a result ...
  • Alexandre, Kabamba B; Gray, ES; Mufhandu, Hazel T; McMahon, JB; Chakauya, E; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (Elsevier, 2012-02)
    It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer to CD4(+) cells. The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and ...
  • Alexandre, Kabamba B; Moore, PL; Nonyane, M; Gray, ES; Ranchobe, N; Chakauya, E; McMahon, JB; O'Keefe, BR; Chikwamba, Rachel K; Morris, L (Elsevier, 2013-11)
    We examined the ability of HIV-1 subtype C to develop resistance to the inhibitory lectins, griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN), which bind multiple mannose-rich glycans on gp120. Four primary HIV-1 ...
  • Mujaju, C; Chakauya, E (2008)
    Sorghum (Sorghum bicolor) is one of the most important cereal crops cultivated in, the semi-arid areas of Zimbabwe where persistent drought, high temperatures and poor edaphic conditions are endemic. Because of their ...
  • Alexandre, Kabamba B; Mufhandu, Hazel T; London, GM; Chakauya, E; Khati, M (Elsevier, 2016-10)
    The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are ...
  • Chakauya, E; Chikwamba, Rachel K; Rybick, EP (Acad Science South Africa, 2006-08)
    This article provides a background to biopharming, highlighting basic considerations for risk assessment and regulation in developing countries, with an emphasis on plant-based vaccines production in South Africa.
  • Chakauya, E; Coxon, KM; Wei, M; MacDonald, MV; Barsby, T; Abell, C; Smith, AG (Springer Verlag, 2008-11)
    Pantothenate (vitamin B5) is the precursor of the 4'-phosphopantetheine moiety of coenzyme A and acyl-carrier protein. It is made by plants and microorganisms de novo, but is a dietary requirement for animals. The pantothenate ...