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Browsing by Author "Swai, HS"

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Detection of antimycolic acid antibodies by liposomal biosensors

Author: Lemmer, Yolandy ; Thanyani, ST ; Vrey, PJ ; Driver, CHS ; Venter, L ; Van Wyngaardt, S ; Ten Bokum, AMC ; Ozoemena, KI ; Pilcher, LA ; Fernig, DG ; Stoltz, AC ; Swai, HS ; Verschoor, JA Date: 2009 Antibodies to mycolic acid (MA) antigens can be detected as surrogate markers of active tuberculosis (TB) with evanescent field biosensors where the lipid antigens are encapsulated in liposomes. Standard immunoassay such as ELISA, where the ... Read more
Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration

Author: Semete, B ; Booysen, L ; Kalombo, Lonji ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study aims to elucidate the ... Read more
In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems

Author: Semete, B ; Booysen, L ; Lemmer, Yolandy ; Kalombo, Lonji ; Katata, L ; Verschoor, J ; Swai, HS Date: Oct 2010 The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some concerns. The aim of ... Read more
In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid

Author: Booysen, LLIJ ; Kalombo, Lonji ; Brooks, E ; Hansen, R ; Gilliland, J ; Gruppo, V ; Lungenhofer, P ; Semete-Makokotlela, Boitumelo ; Swai, HS ; Kotze, AF ; Lenaerts, A ; du Plessis, LH Date: Feb 2013 Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229±7.6 to ... Read more
Lipid containing nanodrug delivery system for the treatment of Tuberculosis

Author: Lemmer, Yolandy ; Semete, B ; Kalombo, Lonji ; Ramalapa, B ; Jones, AT ; Swai, HS ; Verschoor, JA Date: 01 Sep 2010 Challenges in treatment of Tuberculosis (TB) include non-specific localisation of the drugs which results in too low concentrations of the drugs reaching the target site of infection, thus leading to reduced effectiveness. To improve the ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanomedicine: Recent developments and opportunities in Africa

Author: Swai, HS Date: Oct 2012 The author is the principal investigator of the TB Nano drug delivery project which is now going through pre-clinical trials with exciting results, and in this presentation the insights based on the case study will be shared. Read more
Permeation of PLGA nanoparticles across different in vitro models

Author: Nkabinde, LA ; Shoba-Zikhali, LN ; Semete-Makokotlela, Boitumelo ; Kalombo, Lonji ; Swai, HS ; Hayeshi, R ; Naicker, B ; Hillie, TK ; Hamman, JH Date: Jul 2012 Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake ... Read more
Potential of improving the treatment of tuberculosis through nanomedicine

Author: Semete, B ; Kalombo, Lonji ; Katata, L ; Chelule, P ; Booysen, L ; Lemmer, Yolandy ; Naidoo, Saloshnee ; Ramalapa, B ; Hayeshi, R ; Swai, HS Date: Mar 2012 Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a nanotechnology drug delivery system that can be administered in a single dose that maintains ... Read more
Targeted nanodrug delivery systems for the treatment of Tuberculosis

Author: Lemmer, Yolandy ; Semete, B ; Booysen, L ; Kalombo, Lonji ; Katata, L ; Jones, AT ; Alexander, C ; Khati, M ; Swai, HS ; Verschoor, JA Date: Jun 2010 South Africa currently has the highest incidence of TB per 100000 (358 per 100000) people in the world. In 2007 alone 112000 people died of TB in South Africa, of which 94 000 (72%) were co-infected with HIV. Although TB treatments exist, ... Read more

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Browsing by Author "Swai, HS"

Browsing by Author "Swai, HS"

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All of ResearchSpace

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