Author:Van der Westhuyzen, Christiaan W; Haynes, J; Panayides, Jenny-Lee; Wiid, I; Parkinson, CDate:2020Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like ...Read more
Author:Musee, N; Thwala, Melusi; Nota, NDate:May 2011Nanotechnology is currently at the forefront of scientific research and technological developments that have resulted in the manufacture of novel consumer products and numerous industrial applications using engineered nanomaterials (ENMs). ...Read more
Author:Blanchard, Ryan; O'Farrell, Patrick J; Richardson, DDate:Oct 2012Using spatial techniques to determine the threat of land-use change is a useful tool in mitigating against potential biodiversity losses. We investigate the potential suitability and likely impacts of energy crops not currently grown in South ...Read more
Author:Blanchard, Ryan; O'Farrell, PJ; Richardson, DMDate:Apr 2014Liquid biofuel production will likely have its greatest impact through the large-scale changes in land use that will be required to meet the production of this energy source. In this study, we develop a framework which integrates species ...Read more
Author:Nyirenda, KK; Saka, JDK; Naidoo, Dashnie; Maharaj, VJ; Muller, CJFDate:Aug 2012Ethnopharmacological relevance: Communities in Chilumba, Malawi use herbal tea prepared from Fadogia ancylantha Schweinf (Rubiaceae) leaves for the management of diabetes, hypertension and alleviation of symptoms of gastrointestinal disorders ...Read more
Author:Pillay, P; Maharaj, VJ; Clarkson, C; Chibale, KDate:Jan 2007Malaria is the leading cause of death and disease worldwide. The evolution and spread of drug-resistant forms of the causative agent Plasmodium falciparum and the limited number of chemotherapeutic agents available to treat and control the ...Read more
Author:Pillay, P; Maharaj, V; Crouch, N; Smith, P; Lategan, C; Vleggaar, RDate:Feb 2006With the emergence and spread of drug- resistant parasites, there is a need for new chemically diverse, effective antimalarial drugs. A national multidisciplinary consortium was established to validate scientifically South African medicinal ...Read more
Author:Genthe, Bettina; Ndlela, Luyanda L; Madlala, TebogoDate:Dec 2020According to the Centre for Disease Dynamics Economics and Policy, South Africa represents a paradox of antibiotic management similar to other developing countries, with both overuse and underuse (resulting from lack of access) of antibiotics. ...Read more
Author:Adewusi, EA; Fouché, Gerda; Steenkamp, VDate:Oct 2012Traditional healers use Boophane disticha to treat several neurodegenerative diseases. Further studies need to be carried out to justify its use in traditional medicine.Read more
Author:Kamatou, GGP; Viljoen, AM; Steenkamp, PDate:Mar 2010The antioxidant and antiinflammatory activities of the methanol:chloroform (1:1) extracts of 16 Salvia species indigenous to South Africa were evaluated. Antioxidant activity was measured using the 2,20- azino-bis (3-ethylbenzothiazoline-6-sulfonic ...Read more
Author:Kadhila, NP; Sekhoacha, M; Tselanyane, Malefa L; Chinsembu, KCDate:Dec 2018This paper looked at basidiomycetes and their antiplasmodial activities from different studies. The purpose of this short review is to encourage more research on fungi in order to address major and complicated infectious diseases like malaria, ...Read more
Author:Pillay, P; Vleggaar, R; Maharaj, VJ; Smith, PJ; Lategan, CA; Chouteau, F; Chibale, KDate:Feb 2007The dichloromethane extract of the leaves of Vernonia staehelinoides Harv. (Asteraceae) showed in vitro activity (IC50 ~3 µg/ml) against the chloroquine-sensitive (D10) and the chloroquine-resistant (K1) strains of Plasmodium falciparum. ...Read more